News

 

October 2020

NADH and MENOPAUSE

 

The menopause describes the phase in a woman's life after her last menstruation occurs, without removal of the uterus and without taking hormones. You can only really assume that you have had your last period if 12 months have elapsed, which means the menopause can often only be diagnosed in retrospect. The menopause (also known as “the change”) relates to the years when hormone production in the ovaries gradually decreases.

 

The following symptoms can occur due to falling oestrogen production:

 

  • - hot flushes, sweating
  • - insomnia
  • - joint pain
  • - dizziness
  • - depression
  • - anxiety, restlessness, irritability
  • - dryness of the mucous membranes
  • - loss of libido

 

All of these symptoms are directly or indirectly due to a lack of ATP in the cell. This can be compensated for by NADH. NADH is the body's biological hydrogen that reacts with the oxygen in the cell to produce ATP (= adenosine triphosphate) and water. ATP is stored as energy in the mitochondria of the cells and is used for many metabolic reactions. NADH promotes ATP production and thus hormone production and hormonal balance. This means symptoms are improved by taking NADH. The more NADH that enters a cell, the more ATP it can produce.

 

In one study, Friedrich (1) was able to demonstrate the positive effect of NADH on menopausal symptoms. A total of 49 women from Switzerland and Austria aged between 45 and 65 years with menopausal symptoms were tested.

 

The result was impressive. After just 2 months, the following symptoms had improved significantly after taking coenzyme 1 (= NADH):

 

  • - intensity of hot flushes
  • - depression
  • - fatigue
  • - insomnia
  • - listlessness
  • - nervousness

 

In another study by a gynaecologist in Styria, 14 women with menopausal symptoms were treated with NADH for 1 month. The reports from these patients were documented by the doctor and summarised as follows:

 Menopause_table_1

 

Menopause_table_2

 

For decades, the classic treatment by gynaecologists has been hormone replacement therapy. However, studies in recent years have shown that these women have a significantly higher risk of developing breast cancer.

 

NADH helps women lead an active life even during menopause. NADH has no side effects, even in higher doses.

 

Further information can be found on our homepage: www.birkmayer-nadh.com, along with more facts about NADH and the scientific work surrounding it.

 

1.Friedrich F., Nadlinger K., Birkmayer JGD: NADH-Neue Wege in der Behandlung des Klimakterischen Syndroms. J.Menopause 2006,10:10-12
2.Prof. Dr. Dr. George D. Birkmayer: NADH der biologische Wasserstoff, das Geheimnis unserer Lebensenergie

 

NADH and Menopause

 

 

 

 


 

 

August 2020

NADH and SLEEP DEFICIT

 

Sleep deficit is a common problem that leads to fatigue, a lack of energy and a lack of concentration. It affects people with young children, people with sleep problems, people with mental health problems and people with chronic pain.

 

A sleep deficit is dangerous for pilots, flight personnel, doctors, nurses, shift workers, long-distance drivers and people in similar professions because there is an increased risk in these groups that fatigue and poor concentration could lead to accidents. Examples include the nuclear reactor accident in Chernobyl, the sinking of the Exxon Valdez oil tanker off the coast of Alaska and road traffic accidents.

 

NADH is a safe, energy-increasing dietary supplement that also helps people if they are sleep-deficient. NADH helps you to work with more concentration and feel generally fitter and more mentally alert.

 

The positive effect of NADH was demonstrated in a double-blind placebo -controlled study at the Department of Sleep Medicine at Cornell University in NY (1):

 

In this study, 25 healthy men and women aged 40-59 were kept awake for 24 hours. Their waking state was monitored by a 24-hour EEG. One group received 20 milligrams of NADH orally after 24 hours of sleep deprivation, while the other group received a placebo.

 

As a baseline examination, both groups were tested on the morning of the first day after a good night's sleep; the same brain performance tests were carried out on the second day after 24 hours of sleep deprivation and administration of their respective preparations. The results were then compared. It was clear that the results of the NADH group after sleep deprivation were significantly better than those of the placebo group. Both the overall task and visual perception were clearly better in terms of speed and generally.

 

The following graphic (2) shows a particularly impressive result:

 

 

Visual perception and mathematical problem-solving were BETTER with NADH after 24 hours without sleep than in subjects who had taken placebos. The brain performance of the NADH test subjects after 24 hours of sleep deprivation was even better than brain performance after a good night's sleep.

 

This impressive effect of NADH was also presented to the public at a press conference at Cornell University. “Good Morning America” and NEWSWEEK both reported on it.

 

Every reader has probably already experienced how too little sleep leads to physical and mental fatigue. In the laboratory of Professor George Birkmayer, it was also possible to measure this tiredness objectively with the help of a pupillograph.

 

Another study by Georgetown University in Washington (3)(4) on jet lag and sleep deprivation was able to prove that NADH (= coenzyme 1) not only demonstrably increases energy and brain performance, but also improves symptoms such as poor concentration and forgetfulness, disturbed sleep rhythms and depression caused by sleep deprivation.

 

1. Moline ML; Effectiveness of NADH Alleviating Effects of Sleep Deprivation in Healthy Middle-Aged Adults; Study Abstract Cornell University; Sleep Wake Disorder Center December 2001

2. Graphik siehe Buch: Prof. Dr. Dr. George Birkmayer; Der biologische Wasserstoff, das Geheimnis unserer Lebensenergie: S 145

3. Birkmayer JGD, Kay GG, Virre ES;Stabilisiertes NADH (Enada) verbessert die durch Jet Lag reduzierte Hirnleistung (Stabilized NADH as Counter Measure for Jet Lag); Wiener Med. Wochenschr. 2002; 17/18:450-455

4. Birkmayer Joerg; Jet Lag und Schlafentzug-Verminderung der Hirnleistung, Das Coenzym NADH bessert die Symptome; Flugmedizin 2002; 9:41-44

 

 

 

 

 


 

 

July 2020

NADH and SUNSCREEN

 

The summer is here, and with it increased sunlight, which many people like to sit out in and enjoy.

 

Sunburn results from excessive sun exposure. It is not only painful but also leads to premature ageing of the skin and sometimes to skin cancer.

 

As a study by Professor Mustafina (Moscow) (1) has shown, the problem of skin damage and premature skin ageing is based on disruption to the microcirculation of the capillaries (the smallest blood vessels in the body).

 

The capillary microscopy used in this investigation provides real-time information about the state of the microcirculation. This method allows these tiny vessels to be assessed in terms of their density, blood vessel diameter and the width of the effective zone (= perivascularity).

 

This technique showed that the reduced capillary blood flow and the consequent reduced supply of oxygen and energetic substrates into the skin, as well as the reduced removal of metabolic products, result in permanent skin damage.

 

NADH in its liposomal form can re-establish microcirculation, meaning the surrounding tissue can be supplied with energy again, thereby repairing the damaged cells. This heals skin inflammation and stops the skin from ageing. This is achieved solely through the liposomal formulation of NADH in liposomes. These are very small droplets that contain NADH and transport it to the skin. NADH develops its energising effect there in the cutis. Most cosmetics, on the other hand, only treat the skin's surface. For many dermatologists, NADH in its liposomal form is an innovative preparation that delivers real anti-ageing.

 

NADH (= nicotinamide adenine dinucleotide hydride), the biological hydrogen in our body, is in the liposomal form of a patented formulation developed by Prof. George Birkmayer, which contains only one carrier, i.e. lecithin in liposomes. With this, NADH can be transported through the skin and develop its effect there, e.g. in the event of sunburn. The DNA of the skin cells damaged by the sun's rays (UV rays) is also repaired, thus preventing possible degeneration.

 

NADH in the liposomal form also prevents the formation of free radicals, while simultaneously strengthening the immune system and having a positive effect on age spots, wrinkles, acne and toxic dermatitis. Above all, it has a preventive effect when used as a sunscreen and for sun allergies.

 

This is described in more detail in Prof. George Birkmayer's book, "NADH - der biologische Wasserstoff" (2)

 

1. Mustafina F.K., Mustafin T.K., Lasuk A.V., Computergestützte Kapillaroskopie der Haut – ein neues diagnostisches Verfahren in der ästhetischen Medizin, Kosmetik und ästhetische Medizin, 02/2018

2. Prof. George D. Birkmayer, Der biologische Wasserstoff das Geheimnis unserer Lebensenergie (Chapter 9)

 

 

 

 

 

 


 

 

 

June 2020

NADH and DEMENTIA

 

One of the most common diseases in old age is dementia, also known as senile dementia because it usually begins after the age of 65. The wide-spread belief that Alzheimer's and dementia are two different disorders is not true. Alzheimer's is a form of dementia, as are, for example, vascular dementia (VAD) and Lewy body dementia.

 

Typically, the first signs of dementia are short-term memory loss and diminished retentive memory. Patients often gloss over this initial forgetfulness for months or even years, losing valuable time for treatment.

 

Other features of dementia are:

    - forgetfulness, confusion
    - irritability, aggressiveness
    - personality changes
    - depression
    - speech difficulties, loss of communication skills
    - disorientation in space and time.

 

These disorders are caused by a malfunction of the synapses (= connections) in the brain.
Due to this non-functioning cell communication, information cannot be stored and can no longer be processed due to the nerve cells being damaged.

 

A simple method for checking the brain performance of these patients is the Mini Mental State Examination (MMSE).

 

A person's mind can be tested in less than 5 minutes, as follows.

 

    1. Patients are asked 10 orientation questions such as: “What day/month/year is today?”, "What is the date today?", "In which city/country do we live?
    2. Recognition and memory can be checked by the patient having to describe 3 objects named by the examiner.
    3. Attention and concentration are tested by having the patient spell a 5-letter word backwards and repeat a sequence of numbers.
    4. The short-term memory is checked by the patient being asked to name the 3 objects from point 2 again.
    5. Understanding: this is tested by having the patient follow commands given by the examiner, such as: repeating words, making written requests, writing down accurate statements.

 

The maximum score is 30 points for healthy people; less than 24 points indicates reduced brain function. (You can read more about this in section 3.6. of Prof. George Birkmayer's book “NADH, der biologische Wasserstoff, das Geheimnis unserer Lebensenergie”).

The question is: can dementia or other brain disorders be improved or even remedied entirely?

 

The answer is: YES, with NADH.

 

This has been demonstrated by a study at Georgetown University in Washington.

In this study, Alzheimer's patients received 10 mg of NADH per day for 6 months. The brain performance of the patients was determined using standardised tests at the beginning and end of the 6 months. The results were impressive: the patients who received NADH showed significantly better brain performance than the patients who took placebo tablets. By contrast, brain performance deteriorated in the placebo patients.

 

Another study carried out by Professor DEMARIN at the University of Zagreb (1) confirmed the effect of NADH on a large number of Alzheimer's patients (2). NADH not only stops the progression of dementia, it also improves patients’ cognitive performance. The effect of NADH most probably derives from a supply of energy by NADH.

 

Since the human brain consumes about one-third of the energy produced by the organism, ENERGY DEFICIENCY is the most plausible cause of brain disorders. This also explains why NADH, which increases ATP in every cell, has very positive effects on brain performance disorders, especially dementia. That is why NADH is also the best prevention for dementia. It also helps healthy people to stay physically and mentally fit.

 

1. Demarin V, Podobnik-Sarkanji S, Storga-Tomic D, Kay G; Treatment of Alzheimer’s Disease with stabilized oral Nicotinamide Adenine Dinucleotide: A randomized, double-blind study;Drugs exptl. Clin.Res. 2004; 30: 327-337.

2. Demarin V, Podobnik-Sarkanji S, Storga-Tomic D, Kay G, Martinic-Popovic,M. Puretic B., Birkmayer JGD; ENADA/NADH improves cognitive impairment of Alzheimer patients;J. Tumor Marker Oncology 2003; 18:43-49.

 

 

 

 

 

 


 

 

May 2020

NADH and SPORT

 

Every living cell, starting with bacteria all the way up to the human organism, contains NADH (nicotinamide adenine dinucleotide hydride). NADH, also referred to as coenzyme 1, is the biological hydrogen that reacts with the oxygen in the cell and produces water and ATP (adenosine triphosphate). ATP is stored in the mitochondria of the cell and is essential for all cellular processes. This means that the more NADH a cell has available, the more energy it can produce. Especially the brain, heart and muscle cells need an extraordinary amount of energy, which is also why they contain the most NADH.

 

NADH is also present in our food, such as red meat, poultry and fish, and to a lesser extent in vegetables. When preparing our food, the natural NADH supply is often reduced or destroyed.

 

NADH’s energy boosting effects are not only known to have positive outcomes when suffering from depression, Alzheimer’s dementia, Parkinson’s disease, cancer and chronic fatigue, but are also beneficial in healthy and athletic individuals.

 

In a study conducted by Prof. George Birkmayer and Dr. Vank (1) involving 17 well-trained cyclists and marathon runners, the following was observed after these athletes had taken 1 tablet containing 20 mg NADH each morning before breakfast for a period of 4 weeks:

- Quicker reaction time - Improved concentration capacity - A significant reduction in lactate levels - Increase in physical performance and oxygen intake - The spiro-ergometric parameters improved while using NADH

 

Reasons for this improvement could include the following:
1. A possible pre-existing NADH deficiency. 2. An increase in the concentration of dopamine in certain areas of the brain and consequently stimulated muscle growth, given that dopamine stimulates growth hormone (GH) biosynthesis. As a result, the athletes have more strength and more endurance. 3. A stimulation of the cellular ATP energy production caused by NADH, on account of the fact that NADH enters the cell directly.

 

In another study conducted with 4 top athletes, Dr. Bill Missner (2) from the USA revealed the following:

- All athletes improved their sprint performance with NADH (5 minutes cycling, 1 mile running) - Better values from all athletes, also in terms of endurance

 

These findings were verified in a controlled double-blind study at the Institute for Sports Medicine at the University of Freiburg in Germany (3). For the athletes, the practical consequence of this study meant that through regular NADH intake they could train in the aerobic phase for prolonged periods and thereby achieve increased endurance. Creatine kinase (CK), which normally increases during endurance training, indicates that there is damage to the muscle cells. NADH rapidly returns the increased CK activity back to normal again in a very short period of time.

 

Prof. Komi (4) also confirmed these exceptional results in Finland based on his studies involving high-performance athletes.

 

Finally, an important question remains: IS NADH CONSIDERED DOPING?
The IOC (International Olympic Committee) as well as the NADA (National Anti-Doping Agency) were very clear in their answers:
The substance nicotinamide adenine dinucleotide hydride (NADH) does NOT constitute a doping violation.

 

For further information on this topic, please visit www.nada-bonn.de or www.nadamed.de.

 

NADH is the method of choice for people who want to increase their physical energy, vitality and mental capacity with the help of this coenzyme that is produced naturally in the body. It should also be mentioned that no side effects have been observed when consuming higher doses of NADH (200 mg/day).

 

You will find further study results and information regarding NADH preparations at www.birkmayer-nadh.com and in the book “NADH: The Biological Hydrogen: The Secret of Our Life Energy” by Prof. George Birkmayer.

 

 

1. Georg D. Birkmayer, M.D., Ph.D., Pavel Vank, M.D., Birkmayer Institute for Parkinson Therapy, Research Division, Vienna, AUSTRIA: REDUCED COENZYME I (NADH) IMPROVES PSYCHOMOTORIC AND PHYSICAL PERFORMANCE IN ATHLETES; International Journal of Sports Medicine April, 1996

 

2. Bill Misner, Ph.D.(Washington, USA), George D. Birkmayer(Vienna, Austria), H. Schlachter (Munich, Germany), and A. Berg (Freiburg, Germany): THE COENZYMEN NICOTINAMIDE ADENINE DINUCLEOTIDE(NADH) AS A BIOLOGICAL ERGOGENIC FACTOR IN SHORT-TERM AND PROLONGED EXERCISE

 

3. Grathwohl D, Klann M, Müller HM, Schlachter H, Berg A.: Einfluss einer NADH Supplementation auf die muskuläre Energiebereitstellung beim Menschen (Influence of NADH supplementation for the muscular energy supply in humans) Deutsche Zeitschrift für Sportmedizin, 11/2000

 

4. Antti A. Mero, Riikka T. Raitanen, George D. Birkmayer and Paavo V. Komi: EFFECTS OF NICOTINAMIDE ADENINE DINUCLEOTIDE HYDRIDE ON PHYSICAL AND MENTAL PERFORMANCE; Manuscript / Journal of Sports Sciences 19.9. 2006

 

 

 

 

 


 

 

 

April 2020

NADH and cancer

 

How does cancer arise?

 

1. Through genetic changes in the DNA, the hereditary material in the cells.

2. Through a lack of ATP energy in cells. As a result, the cells’ repair mechanisms no longer function properly.

3. Through free radicals.

 

Ad 1)
The DNA can be damaged by many different influences. These include environmental toxins, pesticides, smoking, medication such as chemotherapy, heavy metals like mercury (in tooth fillings), UV light and nuclear radiation. All these factors generate free radicals, which are highly reactive molecules that change our genetic material and so create the basis for cancer to develop.

 

Ad 2)
The production of ATP (= adenosine triphosphate), the cells’ energy store, is controlled by Coenzyme 1, NADH. The more NADH is available to a cell, the more ATP that cell can produce, the better it functions and the longer it lives. An NADH deficiency was found in every investigated cancer cell sample. (1) These cells therefore have an ATP deficiency. This is the biochemical cause for the cancer cells’ uncontrolled division and subsequent formation of metastases. The key question for a plausible cancer treatment is therefore: can one increase the ATP concentration inside cells, and if yes, how? ATP levels can be increased with NADH. This has been demonstrated in isolated heart cells. (2). The oxidised form of NADH, NAD+, and its precursor niacin, however, do not result in increased ATP levels. Administering NADH also increases ATP in the cancer cells, allowing the regulatory molecules to be synthesised in these again and so putting a stop to uncontrolled cell division. The renowned US physician Dr. Thomas COWAN describes in chapter 10 of his book, “CANCER and the NEW BIOLOGY of WATER”, why the form of NADH developed and patented by Prof. George Birkmayer is effective against cancer. He explains that NADH supplies the hydrogen to the cell; this hydrogen then reacts with the oxygen to produce ATP energy and water. Michael D. Forrest of the University of Warwick, Coventry, UK comes to a similar conclusion regarding the positive effects of NADH on cancer (3).

 

Ad 3)
Dr. Richard Passwater also writes in his foreword to my book, “NADH-The energizing Coenzyme”: There is no substance in the human body that one can describe as THE most important or best biological antioxidant, but NADH comes closer to this description than any other biological substance. According to him, NADH is the strongest biological antioxidant and so the best substance for neutralising free radicals.
NADH has been scientifically demonstrated to work effectively against many cancers. The mechanism of action is based on several factors: the modified DNA in cancer cells is repaired through NADH (4). With NADH, the ATP energy in the cancer cells is increased (2), and being the strongest biological antioxidant, NADH neutralises free radicals, one of the causes of cancer (5).
Four of the more than 90 cancer patients who were successfully treated with NADH will be presented; all of them (like many others) were healed with NADH.

 

Patient 1:
A 48-year-old man with small-cell lung cancer, diagnosed in September 2001 through CT, MRI and biopsy and considered inoperable due to the proximity to the mediastinum, received 80 mg NADH/day (4 tablets à 20 mg). Four months later, the tumour had shrunk significantly; after 10 months, it was no longer visible in the MRI scan. The patient has been healthy since May 2002 (so for 18 years).

 

Patient 2:
In 1989, in a 63-year-old woman with breast cancer and liver and bone metastases, a reduction of the metastases was observed after 3 months following treatment with 80 mg NADH/day. After 2 years, all tumour markers in the blood were back to normal and the patient was healthy – and still is today.

 

Patient 3:
A man who had prostate cancer in 1994 received 6 tablets of NADH (20 mg) daily. Six months after administration of NADH, the PSA level dropped from 35 to the normal range of 2.0-5.0. Subsequently, neither ultrasound nor CT could detect a tumour.

 

Patient 4:
A 42-year-old Algerian had a 3.5-cm large medulloblastoma in the cervical vertebrae (diagnosed on 03/08/2013). It left him paralysed in his arms and legs and using a wheelchair.
The patient could not be operated because of the tumour’s location, and he rejected chemotherapy. After daily administration of 160 mg NADH/day (8 tablets NADH à 20 mg), the medulloblastoma was no longer detectable on 28/11/2013 (after 3 months) and the paralysis was gone. The patient was healed, and 6 years later he is still healthy.

 

Conclusion: 
The best way to strengthen your immune system in times like these and to simultaneously improve your cell energy is through NADH. You can find the types of cancer successfully treated with NADH in the book by Univ. Prof Dr med George Birkmayer: “NADH, alles was Sie über NADH (Coenzym1) wissen sollten“ (NADH – Everything you need to know about NADH (Coenzyme 1)) in chapter 10 (NADH bei Krebs/NADH and cancer). This book is available in German and English.

 

 You can read the scientific studies on our homepage https://birkmayer-nadh.com/de/info/publikationen.html.

1. Mikirova, N. et al., Journal of Orthomolecular Medicine 2003, 18, 9-24;

2. Pelzmann, B., et al., Brit.J.Pharm.2003, 139, 749-754 ;

3. Forrest M.D.; https://doi.org/10.1101/019307

4. Zhang J., et al.; J. Tumor Marker Oncol. 1998; 13, 5-17.

5. Fa-Quan L, Zhang JR.; World J. Gastorenterol. 2003, 9(8):1781-1785.

 

 

 

 

 


 

 

March 2020

Nitroxide (NO) inhibits Virus Replication

 

Nitric oxide (NO) is a widespread signalling molecule that participates in virtually every cellular and organ function in the body (1).

 

The main site of the molecule’s synthesis is the inner layer of blood vessels. It relaxes blood vessels and due to this improves the blood flow in the heart and lowers the blood pressure.(2)

 

In the immune system, nitric oxide is produced by macrophages, which are a type of leukocyte (white blood cell) that engulfs bacteria and other foreign particles such as viruses that have invaded the body. Nitric oxide is generated by phagocytes (monocytes, macrophages, and neutrophils) as part of the human immune response.(3) NO is also an effective component in the eradication of viruses. Viral replication is inhibited by the induction of iNOS and the subsequent production of NO. This has been shown for Deng Virus (4), HIV-1, coxsackievirus (5), influenza A and B, rhino virus, CMV and Corona Virus)(6).

 

How can we increase the endogenous NO production ? The source for NO is the amino acid L- Arginine. By the action of the enzyme Nitric Oxide Synthase (NOS) NO is formed from L-Arginine.

 

The enzyme NOS needs the coenzyme NADH (Nicotinamide Adenine Dinucleotide Hydride) for full functionality. As shown by Prof.T. Malinski (Ohio University) the increase of NO-synthesis by NADH supplementation is at least ten times greater than the effect of any other substance). (T. Mailinksi, personal communication). In other words a combination of L-Arginine and NADH increase the endogenous NO production remarkably and can thus destroy the COV-2 virus in infected patients which have developed SARS.

 

There is a nutritional supplement available which contains L-Arginine and NADH, the brand name of which is NADH VISION.

 

References:

(1) The discovery of nitric oxide and its role in vascular biology. Moncada S, Higgs EA. Br J Pharmacol. 2006;147 1:S193–201.

(2) Nitrite as regulator of hypoxic signaling in mammalian physiology. van Faassen, EE; Bahrami, S; Feelisch, M; Hogg, N; Kelm, M; et al. (Sep 2009). Med Res Rev. 29 (5): 683–741.

(3) Cellular mechanisms of nonspecific immunity to intracellular infection: Cytokine-induced synthesis of toxic nitrogen oxides from L-arginine by macrophages and hepatocytes". Green, SJ; Mellouk, S; Hoffman, SL; Meltzer, MS; Nacy, CA (1990). Immunology Letters. 25 (1–3): 15–9. PMID 2126524.

(4) Antiviral action of nitric oxide on dengue virus type 2 replication. Takhampunya R, Padmanabhan R, Ubol S; J Gen Virol. 2006 Oct; 87(Pt 10):3003-11.

(5) Nitric oxide donors inhibit the coxsackievirus B3 proteinases 2A and 3C in vitro, virus production in cells, and signs of myocarditis in virus-infected mice. Zell R, Markgraf R, Schmidtke M, Görlach M, Stelzner A, Henke A, Sigusch HH, Glück B, Med Microbiol Immunol. 2004 May; 193(2-3):91-100.

(6) Nitric oxide inhibits the replication cycle of severe acute respiratory syndrome coronavirus, S. Akerström, M. Mousavi-Jazi, J. Klingström, M. Leijon, A. Lundkvist, A.J. Mirazimi Virol. 79 (2005) 1966–1969.

 

 

 

 

 


 

 

February 2020

Do you suffer from IRRITABLE BOWEL SYNDROME, CROHN’S DISEASE or ULCERATIVE COLITIS? NADH can help you!

 

All three of the diseases mentioned above affect the digestive tract.

 

Irritable Bowel Syndrome (IBS for short) is a condition characterised by symptoms such as abdominal pain, diarrhoea, constipation, bloating and a feeling of not having a complete bowel movement. It can be caused by stress, intestinal infections, nutrition or, as is often the case, a number of these in combination with a genetic predisposition.

 

Ulcerative colitis is a chronic inflammatory disease in which the large intestine (otherwise known as the colon) is affected in particular. Those affected may suffer from painful, bloody, mucousy diarrhoea up to several times a day and even during night, often with the urge to have a bowel movement at night, with cramp-like, colic-like stomach pains, possibly with slight fever, combined with weight loss and fatigue. In ulcerative colitis, only the intestinal mucosa is affected.

 

However, in contrast to this you have Crohn’s disease, where the entire intestinal wall is inflamed. It may be based on an autoimmune disease that can occur throughout the entire digestive tract from the oral cavity to the anus. Crohn’s disease usually begins gradually with abdominal pain and diarrhoea, which persists and leads to weight loss. Elevated blood levels of CRP, blood sedimentation rate and leukocytes can confirm the diagnosis. The distinction between ulcerative colitis and Crohn’s disease can be clarified by a colonoscopy.

 

Having said that, if you undergo targeted therapy with NADH then this distinction is of secondary importance, as we have received feedback from some of our customers who have said that NADH has helped them a lot with these intestinal problems.

 

Mr K. reported the following: “I have been suffering with Crohn’s disease for 20 years now and have had persistent diarrhoea and sometimes excruciating stomach pains. I always needed a toilet within a 20m radius as I would not be able to control the urge to pass a bowel movement.Travelling, meeting up with friends or going to work was out of the question. I felt like a prisoner locked up at home.

After taking 2 x 4 NADH tablets every day, I’ve become a new person.

It wasn’t long at all before I was able to pass solid stools again for the first time, I was able to go out of the house again, I gained weight and I have much more energy to tackle life again.

I have rediscovered the JOY OF LIFE and my QUALITY OF LIFE has increased enormously.”

 

For people who want to feel healthy again or stay healthy!

 

 

 

 

 


 

 

January 2020

NADH and NAD+ – What is the difference?

 

The key difference between NADH and NAD+ is that NADH has been shown to enter the cell and increase ATP energy production in the cell.

 

Consequently, if the cell has more energy, it can produce all molecules necessary for cell regulation in sufficient quantities.

 

NAD+ does NOT enter the cell and can therefore not form ATP. This has been proven in the study (1). Also the NAD+ precursors such as nicotinamide ribosides or NMN (nicotinamide mono nucleotides) do not pass through the cell membrane because they are both positively charged molecules. These molecules cannot penetrate the cell membrane's lipid layer. This statement is clearly illustrated in the following diagram.

 

 

More than 50 scientific studies have been published about the biological functions and therapeutic effects of NADH, and there have also been many studies published about the safety and absence of side effects of NADH (2).

 

The following facts demonstrate the difference between NADH and NAD+: NAD+ has only been the subject of sporadic scientific studies. To date, a single study on the tolerability of NAD+ has been conducted using 8 (eight) healthy middle-aged people. The unsurprising result was that the 8 participants tolerated NAD+ well (3). Nevertheless, the NAD+ molecules are too large and therefore cannot diffuse through the cell membrane. It is also important to note that NAD+ in its pure form is NOT a nutrient and therefore cannot be taken with food or with food supplements (4).

 

Clinical studies show that NMN supplements increase NAD+ to a youthful level. NADH, however, is found in many types of food and is available as a dietary supplement around the world. NADH also has at least 3 scientifically proven anti-aging effects (5,6,7). There are 3 main phenomena responsible for aging: (a) Decrease of ATP - energy production in the cells. NADH increases ATP energy production in the cell (1) (b) Damage to the DNA as a result of environmental toxins, radiation and chemotherapy. NADH can repair DNA and cells that have been damaged (8). (c) Oxidation and damage to the cell membrane. NADH acts as a strong biological antioxidant (9). NAD+ being the oxidised form of NADH can NEVER act as an antioxidant.

 

References:

1. “NADH-supplementation decreased pinacidil-primed I K(ATP) in ventricular cardiomyocytes by increasing intracellular ATP” Pelzmann B, Hallström S, Schaffer P, Lang P, Nadlinger K, Birkmayer GD, Vrecko C, Reibnegger G and Koidl B. Brit. J. Pharm. 2003 139,749-754.

2. https://birkmayer-nadh.com/en/info/publications.html

3. “An open-label, non-randomized study of the pharmacokinetics of the nutritional supplement nicotinamide riboside (NR) and its effects on blood NAD+ levels in healthy volunteers”. Airhart, S. E., Shireman, L.M., Risler, L.J., Anderson, G. D., Nagana Gowda, G. A., Raftery, D., et al. (2017). PloS One 12:e0186459. doi: 10.1371/

4. Opinion no 018/2012 of the German Federal Institute for Risk Assessment (BfR) dated 06 February 2012

5. “Coenzym-1 (N.A.D.H.): A Proven Anti-Aging Substance” Birkmayer JGD, Abstr.Comm. 1st European Congress on Anti-Aging Medicine October 18 -21, 2006 Vienna, Austria

6. “Coenzym-1 (NADH) - Eine wissenschaftlich bewiesene Anti-Aging-Substanz” Birkmayer JGD, Prevention and anti aging 2006 340-348

7. “Method of prolonging the Life-span of Living Cells using NADH, NADPH and ADP-Ribose” Birkmayer JGD, Nadlinger K, Hallstöm S, Westerthaler W, US-Patent Pub.No. US 2004 / 0126751

8. The Reduced Coenzyme Nicotinamide Adenine Dinucleotide (NADH) repairs DNA damage of PC12 cells induced by doxorubicin; Zhang JR, Vrecko K, Nadlinger K, Storga D, Birkmayer GD, Reibnegger G J. Tumor Marker Oncol. 1998; 13, 5-17.

9. “The antioxidative capacity of ENADA®-NADH in humans”; Reibnegger G, Greilberger J, Juergens G. and Oettl K.J. Tumor Marker Oncol. 2003; 18, 37-41.