Publications

 

 

Effects of NADH

 

NADH-supplementation decreased pinacidil-primed I K(ATP) in ventricular cardiomyocytes by increasing intracellular ATP

Pelzmann B, Hallström S, Schaffer P, Lang P, Nadlinger K, Birkmayer GD, Vrecko C, Reibnegger G and Koidl B.

Brit. J. Pharm. 2003 139, 749-754.

 


 

The Reduced Coenzyme Nicotinamide Adenine Dinucleotide (NADH) repairs DNA damage of PC12 cells induced by doxorubicin

Zhang JR, Vrecko K, Nadlinger K, Storga D, Birkmayer GD, Reibnegger G

J. Tumor Marker Oncol. 1998; 13, 5-17.

 


 

X-ray induced LO2 cells damage rescued by new antioxidant NADH

Fa-Quan L, Zhang JR.

World J. Gastorenterol. 2003, 9(8): 1781-1785.

 


 

The Reduced Coenzyme Nicotinamide Adenine Dinucleotide (NADH) rescues PC 12 cells from Apoptosis

Zhang JR, Vrecko K, Nadlinger K. Storga D. Birkmayer GD, Reibnegger G

J. Tumor Marker Oncol. 1998; 13(3): 11-24.

 


 

The Cytoprotection of Nicotinamide Adenine Dinucleotide (NADH) by the Mitochondrial Regulation Mechanism

Meng Xu, Hang JR, Hui SSC

J. Tumor Marker Oncol. 1998; 17: 167 - 174.

 


 

The reduced coenzyme Nicotinamide Adenine Dinucleotide (NADH) prevent hepatic cells from Apoptosis

Meng Xu, Jiren Zhang

Int. Journal of Modern Cancer Therapy 2000: 3, 38 - 41.

 


 

The antioxidative capacity of ENADA®-NADH in humans

Reibnegger G, Greilberger J, Juergens G. and Oettl K.

J. Tumor Marker Oncol. 2003; 18, 37-41.

 


 

Oral NADH effects blood pressure, lipid peroxidation and lipid profile in spontaneously hypertensive rats

Busheri N, Taylor J, Lieberman S, Mirdamadi-Zonosi N, Birkmayer G, Preuss HG

Geriat. Nephrol. Urol. 1998; 18(2) 95-100.

 


 

Influence of reduced Nicotinamide Adenine Dinucleotide (NADH) on the production of Interleukin-6 by peripheral human blood leucocytes

Nadlinger K, Birkmayer J, Gebauer F, Kunze R

Neuroimmunomodulation, 2002; 9: 203-208.

 


 

NADH stimulates endogenous dopamine biosynthesis by enhancing the recycling of tetrahydrobiopterin in rat phaechromocytoma cells

Vrecko K, Storga D, Birkmayer GD, Möller R, Tarfeit E, Horejsi R, Reibnegger G

Biochimica et Biophysica Acta 1997; 1361: 59-65.

 


 

Effects of acute and chronic NADH Administration on Peripheral and Central Norepinenphrine and Dopamine Synthesis in the Rat

Gardier AM

Birkmayer Institute for Parkinson Therapy, Internal Lab Report No. 94070401.

 


 

NADH: Sensor of blood flow in brain, muscle and other tissues

Ido Y., Chang K., Woosley TA, Willimanson JR

FASEB, 2001; 15: 1419- 1421.

 


 

Reduced nicotinamide nucleotides prevent nitration of tyrosine hydroxylase by peroxinitrite

Kuhn DM, Geddes TJ.

Brain Research 2002; 933: 85-89.

 


 

NAD+ dependent repair of damaged DNA by human cell extracts

Satoh MS, Pirier GG, Lindahl T.

Biol. Chem. 1993; 268; 8: 5480-5487.

 

 

 

 

Stability, Bioavailablity and Safety of NADH

 

Stable, ingestable and absorbable NADH and NADPH therapeutic compositions

Birkmayer JGD.

United States Patent No. 5.332.727, 1994.

 


 

Stable, ingestable and absorbable NADH and NADPH therapeutic compositions

Birkmayer JGD.

European Patent EP 0 697859, 1995.

 


 

Investigational New drug Application Birmadil™ Tablets 5mg containing reduced ß-nicotinamide adeninie dinucleotide for Treatment of Dementia of the Alzheimer’s Type

Birkmayer Pharmaceuticals

IND Number 49,766 1996.

 


 

Bioavailability of reduced nicotinamide-adenine-dinucleotide (NADH) in the central nervous system of the anaethesized rat measured by laser-induced fluorescence spectroscopy

Rex A, Hentschke MP, Fink H

Pharmacol. Toxicol. 2002; 90: 220-228.

 


 

Zur Entwicklung von stabilen Arzneiformen des Coenzyms NADH für die perorale und parenterale Applikation

Mattern C. Ph.D.

Dissertation Humboldt Universität, Berlin, 1996.

 


 

Untersuchungen zur Pharmakokinetik von NADH in vivo und in vitro

Kappes K.

Digitale Dissertation, FU Berlin 2005. ISBN 3-886664-054-4.

 


 

On the Safety of Reduced Nicotinamide Adenine Nucleotide (NADH)

Birkmayer JGD, Nadlinger K, Hallström S.

Journal Environmental Pathology, Toxicology and Oncology 2004; 23: 179-194.

 


 

Safety of stabilized, orally absorbable, reduced nicotinamide adenine dinucleotide (NADH): A 26-week oral tablet administration of ENADA®/NADH for chronic toxicity study in rats

Birkmayer JGD, Nadlinger K.

Drugs experimental clinical Research 2002; 28: 185-182.

 

 

 

 

Applications and Beneficial Effects of NADH

 

Parkinson’s Disease

 

Nicotinamide adenine dinucleotide (NADH) - a new therapeutic approach to Parkinson’s disease: Comparison of oral and parenteral application

Birkmayer JGD, Vrecko C, Volc D, Birkmayer W

Acta Neurol Scand. 1993; 87: 32-35.

 


 

Stimulation of the endogenous L-dopa biosynthesis - a new principle for the therapy of Parkinson’s disease: the clinical effect of nicotinamide adenine dinucleotide (NADH) and nicotinamide adenine dinucleotidephosphate (NADPH)

Birkmayer JGD, Birkmayer W.

Acta Neurol Scan. 1989; 126:183-187.

 


 

Stimulation of dopamine biosynthesis in culture PC12 pheochromocytoma cells by the coenzyme nicotinamide adenine dinucleotide (NADH)

Vrecko K, Birkmayer JGD, Krainz J.

J.Neural.Transm. 1993; 5: 147-156.

 

 

 

Depression

 

The reduced nicotinamide adenine dinucleotide (NADH) as biological antidepressive agent. Experience with 205 patients

Birkmayer JGD, Birkmayer W

New trends in Clinical Neuropharmacology 1991; 5: 75-86.

 


 

Antidepressant-like effect of nicotinamide adenine dinucleotide in the forced swim test in rats

Rex A, Schickert R, Fink H

Pharmacology, Biochemistry and Behaviour 2004; 77: 303-307.

 

 

 

Chronic Fatigue

 

The therapeutic effect of NADH in patients with Chronic Fatigue Syndrome

Forsyth L, Preuss. H, Carneiro ML, Chiazze R, Birkmayer GD, Bellanti J

Ann. Allergy Asthma and Immunol., 199.9; 82: 185-191.

 


 

Functional Herbal Medicines & Dietary Supplements

Mertens G

Nicholas Hall & Company, 2000; S.17-23.

 


 

Die Wirkung von oralem NADH bei Symptomen des Chronischen Müdigkeitssyndroms

Birkmayer JGD

Journal Orthomolekulare Medizin, 1999; 2: 107-116.

 


 

NADH improves symptoms of patients with chronic fatigue syndrome

Birkmayer JGD

The Original Internist; 1999; 6: 6-8.

 

 

 

Dementia of the Alzheimer Type

 

Treatment of Alzheimer’s Disease with stabilized oral Nicotinamide Adenine Dinucleotide: A randomized, double-blind study

Demarin V, Podobnik-Sarkanji S, Storga-Tomic D, Kay G

Drugs exptl. Clin.Res. 2004; 30: 327-337.

 


 

ENADA/NADH improves cognitive impairment of Alzheimer patients

Demarin V, Podobnik-Sarkanji S, Storga-Tomic D, Kay G, Martinic-Popovic,M. Puretic B., Birkmayer JGD

J. Tumor Marker Oncology 2003; 18:43-49.

 


 

Improvement of Verbal Fluency in Alzheimer’s Disease After NADH Treatment

Demarin V, Storga-Tomic D, Bosnar-Puretic M, Martinic-Popovic I, Birkmayer J

Proceedings 7th Congress European Society for Clinical Neuropharmacology ed: Medimond 2004; 41-45.

 

 

 

Cancer

 

NADH in Cancer Prevention and Therapy” in Phytopharmaceuticals in Cancer Chemoprevention

Birkmayer JGD, Zhang JR, ed. Bagchi D, Preuss H

CRC Press 2005; chapter 33, 541- 554.

 

 

 

Physical and Mental Performance

 

Einfluss einer NADH Supplementation auf die muskuläre Energiebereitstellung beim Menschen (Influence of NADH supplementation for the muscular energy supply in humans)

Grathwohl D, Klann M, Müller HM, Schlachter H, Berg A.

Deutsche Zeitschrift für Sportmedizin, 11/2000.

 


 

ENADAlert® improves physical and mental performance in highly conditioned athletes

Birkmayer GD, Nadlinger K.

J. Tum. Marker Oncol. 2003; 18: 51-55.

 


 

Extracellular metabolization of NADH by blood cells correlated with intracellular ATP levels

Nadlinger K, Westerthaler W, Storga-Tomic D, Birkmayer JGD

Biophys. Biochim Acta 2002; 1573: 177-182.

 

 

 

Jet Lag and Sleep Deprivation

 

Assesssing the Efficacy of Pharmaceuticals and Nutraceuticals as Countermeasures for Jet Lag

Virre ES, Kay GG

Abstr. Commun. 7th Conference Int. Society Travel Medicine 2001; FC06.03.

 


 

Effectiveness of NADH in Alleviating Effects of Sleep Deprivation in Healthy Middle-Aged Adults

Moline ML.

Study Abstract Cornell University, Sleep Wake Disorder Center December 2001.

 


 

Stabilisiertes NADH (ENADA) verbessert die durch Jet Lag reduzierte Hirnleistung (Stabilized NADH as Counter Measure for Jet Lag)

Birkmayer JGD, Kay GG, Virre ES

Wiener Med. Wochenschr. 2002; 17/18: 450-454.

 


 

Jet Lag und Schlafentzug - Verminderung der Hirnleistung Das Coenzym NADH bessert die Symptome

Birkmayer Joerg

Flugmedizin 2002; 9: 41-44.

 


 

Stabilized NADH (ENADA) as Counter-Measure Jet Lag and Sleep Deprivation

Kay GG, Virre ES, Moline M

J. Tumor Marker Oncol. 2001; 16 : 124-125.

 


 

Stabilisiertes NADH (ENADA) verbessert die Symptome von Schlafentzug und Jet Lag

Birkmayer JGD

Med. Welt 2001; 7: 61.

 


 

NAD+ and NADH in brain functions, brain diseases and brain aging

Ying W.

Frontiers in Bioscience 2007; 12:1863 - 88.

 


 

NAD+ and NADH in cellular functions and cell death

Weihai Ying

Frontiers in Bioscience 2006; 11, 3129 - 3148.

 

 

 

Menopause

 

NADH - neue Wege in der Behandlung des klimakterischen Syndroms

Friedrich F, Nadlinger K, Birkmayer JGD, Friedrich F

J. Menopause 2006, 10:10-12.

 


 

Coenzym-1 (N.A.D.H.) verbessert die Symptome des klimakterischen Syndroms

JGD Birkmayer

Geburtsh Frauenheilk 2006; 67

 

 

 

Anti-Ageing

 

Coenzym 1 (N.A.D.H.): A Proven Anti-Aging Substance

Birkmayer JGD

Abstr.Comm. 1st European Congress on Anti-Aging Medicine Oct. 18-21, 2006 Vienna, Austria

 


 

Coenzym-1 (NADH) - Eine wissenschaftlich bewiesene Anti-Aging-Substanz

Birkmayer JGD

Prevention and anti aging 2006: 340-348.

 


 

Method of prolonging the Life-span of Living Cells using NADH, NADPH and ADP-Ribose

Birkmayer JGD, Nadlinger K, Hallstöm S, Westerthaler W

US-Patent Pub.No. US 2004 / 0126751

 

 

 

Cosmetic and Dermatological Applications

 

NADH and NADPH therapeutic Agents for nasal, sublingual, rectal and dermal administration

Birkmayer JGD

United States Patent Nr. 5,952.312 1999.

 


 

Ointment Preparation containing NADH in Teleangiectasis

Augustin M, Zschocke I

Final Biometric Report, Universitäts Hautklinik, Freiburg, Germany Okt. 2000.

 


 

ENACHI Skin Serum - An innovative unique cosmetic product based on ENADA™- NADH

Birkmayer JGD

Nutraceuticals Now 2005; 44-45.

 

 

 

NADH monographies

 

NADH - The energizing Coenzyme

Birkmayer George D.

Keats Good Health, Keats Publishing, Inc. 1998.

 


 

NADH - Biologische Funktionen und ernährungsphysiologische Anwendungen

Joerg Birkmayer

ERNO 2000; 1: 71 - 76

 


 

NADH - Alles was Sie über NADH (Coenzym-1) wissen sollten

Univ.Prof. Dr.Dr. Joerg Birkmayer

Eine Broschüre zur Information vom Ärzten und Therapeuten, Eigenverlag, 2009

 


 

NADH - the biological hydrogen - the secret of our life energy

Birkmayer George

Basic Health Publications Inc. USA, 2009